Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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JR_AJP-12-4_009

تاریخ نمایه سازی: 27 اردیبهشت 1401

Abstract:

Objective: The clinical use of tacrolimus is limited due to its side effects. This research investigated the protective activities of pomegranate seed oil (PSO) against TAC toxicity.Materials and Methods: The groups are included normal (۱ ml of corn oil), TAC (۲ mg/kg), and co-treatment of PSO (۰.۴ and ۰.۸ ml/kg) and TAC. All administrations were carried out intraperitoneally for ۱۴ days. After the last injection, blood was collected from the heart.Results: TAC increased creatinine and urea. Increased malondialdehyde, reduced thiol content and superoxide dismutase. The elevation of lactate dehydrogenase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine kinase-MB and creatinine phosphokinase that confirmed cardiac toxicity. PSO reduced TAC toxicity. PSO decreased TAC-induced pathology injury.Conclusion: PSO reduced TAC toxicity in renal and heart via scavenging free radicals.

Authors

Azar Hosseini

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Arezoo Rajabian

Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Fatemeh Forouzanfar

Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mahdi Farzadnia

Cancer Molecular Pathology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Taher Boroushaki

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran