Effect of electrical stimulation of central nucleus of the amygdala on morphine conditioned place preference in male rats
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 25، Issue: 5
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-25-5_008
تاریخ نمایه سازی: 21 خرداد 1401
Abstract:
Objective(s): The central nucleus of the amygdala (CeA) is one of the most important areas for the morphine reward system. This study investigated the effect of electrical stimulation of CeA on morphine conditioned place preference (CPP) in male rats. Materials and Methods: After anesthetizing male Wistar rats, both electrode and cannula were implanted into CeA for stimulating (low intensity: ۲۵ μA, and high intensity: ۱۵۰ μA) and injecting (lidocaine and dopamine D۲ receptor antagonist), respectively. Then, CPP induced by effective (۵ mg/kg) and ineffective (۰.۵ mg/kg) doses of morphine was evaluated for five consecutive days (n = ۶ / group).Results: The low electrical stimulation intensity of ۲۵ μA suppressed both acquisition and expression phases, but the high intensity of ۱۵۰ µA attenuated only the expression phase. On the other hand, intra-CeA administration of dopamine D۲ receptor antagonist, eticlopride (۲ µg/rat), with the effective dose of morphine, decreased CPP. In addition, infusion of lidocaine into the CeA inhibited morphine-induced CPP in both acquisition and expression phases with the effective dose of morphine.Conclusion: Electrical stimulation of the CeA may play an important role in attenuating morphine induced CPP via possible changes in neurotransmitters involved in the reward system such as dopamine (DA) and gamma-aminobutyric acid (GABA).
Keywords:
Addiction , Central nucleus of amygdala , Deep brain stimulation , Dopamine D۲ receptor - antagonist , Morphine , Rat
Authors
Zahra Jokar
Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
Saeed Khatamsaz
Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
HojjatAllah Alaei
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Mehrdad Shariati
Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
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