In Vivo Antinociceptive Effects of Persian Shallot (Alliumhirtifolium) in Male Rat

Background: The tendency toward using herbal plants instead of synthetic drugs is increasing in recent years because of their lower adverse effects and high varieties of efficient components. Objectives: In this investigation, analgesic effects of hydroalcoholic leaf extract of Alliumhirtifolium were studied in male rats. Materials and Methods: A total of ۴۸ adult male rats were divided eight groups: control, intraperitoneal ۵۰, ۱۰۰, and ۲۰۰ mg/kg of extract, ۲۰۰ mg/kg of A.hirtifolium extract plus aspirin, aspirin (۱ mg/kg), morphine (۱ mg/kg), and ۲۰۰ mg/kg of A.hirtifolium extract plus naloxone (۱ mg/kg). The analgesic effects of A.hirtifolium were assessed with writhing, tail-flick, and formalin tests. The data were compared with control by one-way ANOVA and Tukey post hoc test. Results: Alliumhirtifolium extract at (۲۰۰ mg/kg dosage), alone and in combination with aspirin, had shown antinociceptive effect in writhing, tail-flick, and formalin tests (P < ۰.۰۱). Alliumhirtifolium extract (at ۱۰۰ mg/kg dosage) had just shown analgesic effects on tail-flick and formalin (chronic phase) tests. Conclusions: It looks that A. hirtifolium has antinociceptive effects that might be due to flavonoids and saponins in plant the analgesic effect of which was demonstrated previously.

Keywords:

Allium hirtifolium , Formaldehyde , Saponins , Flavonoids