Evaluation overexpression of miR-۴۵۱a in decreased CERK gene expression in breast cancer using bioinformatics analysis

MicroRNAs (miRNAs) are one of the essential components of gene regulatory networks today. MiRNAs candown-regulate gene expression by inhibiting translation or stimulating mRNA degradation. In some cases,they can also up-regulate the target gene. MiRNAs participate in regulating biological processes and therebyhave the promising potential to act as valuable diagnostic biomarkers and even therapeutic molecules invarious diseases.Bioinformatics analysis is a pivotal initial step of microRNA research, starting from searching, targeting,interaction. In our study, we used bioinformatic analysis data to find out (۱) the expression of miR-۴۵۱a (۲),the expression of miR-۴۵۱a in breast cancer compared to other miRNAs (۳), miR-۴۵۱a target prediction (۴),Interaction between miR-۴۵۱a and cerk (۵) the link between miR-۴۵۱a and breast cancer. Finally,bioinformatics is continuing the development of new tools in the future and in the world, so it is more helpfulfor cancerous diseases and attractive in molecular therapy.

Keywords:

breast cancer , MicroRNAs , miR-۴۵۱a , cerk