Experimental investigation of the oxygen sensing ability of positron annihilation spectroscopy for tumor imaging
Publish place: Radiation Physics and Engineering، Vol: 3، Issue: 3
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RPE-3-3_001
تاریخ نمایه سازی: 5 تیر 1401
Abstract:
The potential biomedical application of Positron Annihilation Spectroscopy (PAS) for nonstructural characterization of normal and cancer cells was not thoroughly employed and researched. In this paper, the experimental investigation of the oxygen sensing ability of the PAS technique for tumor imaging is presented and discussed. This research is based on the validated hypothesis that tumor cells differ from the normal tissues in their value of oxygen concentrations. The components of Doppler Broadening and positron annihilation lifetime spectra are measured with our homemade spectrometer to determine the mechanism behind the positron annihilation in oxygen content tissue-equivalent samples. The analysis of PAS data shows that the Orbital Momentum Spectrum (OEMS) of the Coincidence Doppler Broadening Spectroscopy (CDBS) and the positronium lifetime components of Positron Annihilation Lifetime Spectroscopy (PALS) are sensitive to the presence of oxygen. The results are applicable in the development of a tumor imaging system based on the PAS technique.
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Authors
Mahshid Zare
Nuclear Engineering School, Shahid Beheshti University, Tehran, Iran
Behjat Ghasemi
Nuclear Engineering School, Shahid Beheshti University, Tehran, Iran
Omid Reza Kakuee
Physics and Accelerators Research School, Nuclear Science and Technology Research Institute, P. O. Box ۱۴۳۹۵-۸۳۶, Tehran, Iran
Ali Biganeh
Physics and Accelerators Research School, Nuclear Science and Technology Research Institute, P. O. Box ۱۴۳۹۵-۸۳۶, Tehran, Iran
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