Evaluation of ventricular tachyarrhythmias in patients with myocardial infarction after streptokinase therapy

Objectives: The occurrence of arrhythmias after myocardial infarction is associated with an increased risk of mortality. The purpose of this study was to investigate tachyarrhythmias after streptokinase therapy in myocardial infarction patients.Methods: This study was a case-control study. Among ۲۶۲ patients with myocardial infarction who received streptokinase, ۱۶۸ patients with ventricular tachyarrhythmia, ventricular fibrillation, or both (case group), and ۹۴ patients without arrhythmia (control group) were selected. Their clinical information were collected by questionnaire. Data were analyzed using SPSS ۲۰ software through Chi-square test and Wilcoxon rank-sum.Results: There was no relationship between demographic variables or electrocardiogram changes and the type of arrhythmia in ۱۶۸ participants in the group ۱ (p > ۰.۰۵). However, there was a significant relationship between age (p = ۰.۰۴), sex (p = ۰.۰۴۹), diabetes (p = ۰.۰۳۹), hypertension (p = ۰.۰۳۷), history of beta-blocker use (p = ۰.۰۲۸), history of aspirin use (p = ۰.۰۲۳), number of the leads involved (p = ۰.۰۲۳) and occurrence of arrhythmia among the participants in group ۲.Conclusions: According to the findings of this study, patients with myocardial infarction who need to receive thrombolysis and who have any of the following conditions should be monitored by the health care staff to prevent development of ventricular tachyarrhythmias: old age, male gender, history of diabetes mellitus, hypertension or more lead involvement in their electrocardiogram.

Keywords:

Cardiac arrhythmia , Electrocardiography , Myocardial infarction , Streptokinase therapy