Quantitative assessment of salivary gland function by radioisotopic scanning in a randomized trial of Pilocarpine for prevention of radiation induced Xerostomia [Persian]

Publish Year: 1380
نوع سند: مقاله ژورنالی
زبان: English
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JR_IRJNM-9-1_005

تاریخ نمایه سازی: 7 تیر 1401

Abstract:

Introduction: Radioisotope scanning is the best method for objective assessment of salivary gland function. Thus, it was used in a randomized trial of concomitant pilocarpine for assessment of radiation-induced xerostomia, in addition to subjective evaluation by an approved questionnaire and objective standard xerostomia grading. Methods: Patients randomized in placebo-controlled trial of pilocarpine concurrent with irradiation for prevention of radiation-induced xerostomia were evaluated by salivary gland scintigraphy immediately before and ۶ months after the end of head and neck radiotherapy. Salivary gland function was measured by ejection fraction (EF) of Technetium-۹۹m pertechnetate. The mean values for pre and post-radiotherapy scans were calculated and compared. Also post-radiotherapy scan findings in the two groups of pilocarpine and placebo were compared using the student’s t-test. In addition, comparison was made between the scan results and the subjective findings and objective gradings. Results: Twenty patients underwent the pre-radiotherapy salivary scintigraphy, and also ۲۰ post-radiotherapy scans were performed. Mean parotid EF was ۶۰.۸۵% in the pre-radiotherapy and ۹.۰۸% in the post-radiotherapy scans (P<۰.۰۱). The means for submandibular glands in the pre and post-radiotherapy scans were ۴۱% and ۱۱.۲%, respectively (P<۰.۰۱). Also the mean EF was ۱۴.۵% in the pilocarpine group and ۳.۶۵ in the placebo group for parotid glands (P=۰.۰۷) and ۱۸.۳% and ۴.۱% respectively for submandibular glands (P<۰.۰۵). The salivary scans confirmed the subjective and objective xerostomia findings. Conclusion: Salivary gland scintigraphy is a valuable method for evaluation of xerostomia after head and neck radiotherapy, quantitatively demonstrating the protective effect of pilocarpine compared to placebo on salivary glands.

Authors

Armaghan Fard-Esfahani

Research Institute for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Mehdi Modarress Mosalla

Research Institute for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

Peiman Haddad

Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Eftekhari

Research Institute for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

Mohsen Saghari

Research Institute for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran