The optimal time of discountinuing Methimazole before radioiodine therapy [Persian]
Publish place: Iranian Journal of Nuclear Medicine، Vol: 9، Issue: 1
Publish Year: 1380
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IRJNM-9-1_008
تاریخ نمایه سازی: 7 تیر 1401
Abstract:
Hyperthyroidism is a common disease and one of the best methods for its treatment is radioiodine therapy. Treatment with antithyroid drugs brings patients to euthyroidism before radioiodine therapy. Antithyroid drugs should be discontinued before radioiodine therapy to increase thyroid uptake. The purpose of this study was to determine the optimal time of methimazole (MTZ) discontinuation. One hundred eighty four patients, who were referred for radioiodine therapy were classified in ۳ groups according to the duration of MTZ discontinuation before thyroid uptake (RAIU) measurement. Group ۱, ۲ and ۳ were patients who discontinued MTZ (۴۸-۷۲ hrs), (۷۲-۱۲۰ hrs) and more than ۱۲۰ hrs before RAIU measurement, respectively. Mean thyroid uptake in group ۱, ۲ and ۳ was (۶۴±۱۵.۱%), (۶۰.۱±۱۴.۱%) and (۵۹.۳±۱۲.۸), respectively. No significant difference was noted in thyroid uptake between these groups (F=۱.۸۳, P<۰.۱۶). This study shows that ۴۸-۷۲ hrs of MTZ discontinuation before radioiodine therapy is enough and longer term abstention is not associated with higher uptake.
Authors
Zohreh Moosavi
Mashhad University of Medical Sciences, Mashhad, Iran
Seyed Rasoul Zakavi
Mashhad University of Medical Sciences, Mashhad, Iran