Distribution of I-۱۲۵-IgG in normal and induced inflammation in mice [Persian]
Publish place: Iranian Journal of Nuclear Medicine، Vol: 7، Issue: 1
Publish Year: 1378
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IRJNM-7-1_009
تاریخ نمایه سازی: 7 تیر 1401
Abstract:
Antibodies are a diverse class of glycoproteins that specially bind with antigen and elicit a number of secondary responses in vivo. Most of the applications of antibodies in basic research diagnosis and immunotherapy rely on labeling of the antibody with radiopharmaceuticals. Radiolabeled antibodies are a new class of imaging agents for the detection of sites of disease. True biodistribution of IgG has a great importance to develope antibody conjugates for delivering radionuclides or drugs to desired sites. In this study, IgG was iodinated by chloramine-T method. Injecting turpentine in the left thigh of mice induced inflammation. Distribution of I-۱۲۵-IgG in normal and induced inflammation mice was assessed. Results showed the accumulation of I-۱۲۵-IgG in inflammed muscle was more than normal muscle.
Authors
Mohammad Hossein Babaei
Department of Radioisotope, Nuclear Research Center, AOEI, Tehran, Iran
Reza Najafi
Department of Radioisotope, Nuclear Research Center, AOEI, Tehran, Iran
Soraya Shahhosseini
Shahid Beheshti University of Medical Sciences, Tehran, Iran