Comparison of Tc-۹۹m Ethylenedicysteine (Tc-۹۹m EC) with Tc-۹۹m DPTA in evaluation of renal disease [Persian]

Tc-۹۹m-EC is a new renal radiopharmaceutical introduced as an alternative for Tc-۹۹m MAG۳. Twenty-three normal volunteers and patients in different .stages of renal disease were evaluated with Te-۹۹m EC and Tc-۹۹m DTPA. The mean initial uptake of EC was significantly higher as compared to DTPA. There was a high correlation between rectangular and hand-drawn ROls for kidney and background, ۰.۹۶ and ۰.۹۴ for right and left kidney, respectively. There was no significant difference between supra and subrenal background activities. A high correlation was also noticed between renal uptake of both agents divided by their injected original dose, and with correlation coefficient of ۰.۸۸ and ۰.۸۵ for the right and left kidneys, respectively. The relative right kidney uptake of two agents was nearly similar (with correlation coefficient of ۰.۹۲). The quality of the renogram generated with EC was belter than those obtained with DTPA. The results show that Tc-۹۹m EC has good characteristics to be used as an agent for evaluation of renal function and morphology.