Prognostication of Sino-Nasal Mucormycosis

Introduction: For the purpose of prognostication of sinonasal mucormycosis, a detailed analysis of the clinical, diagnostic, therapeutic and outcome parameters has been contemplated. Materials and Methods: Retrospectively data was collected for all patients of sinonasal mucormycosis managed in a tertiary care hospital in last ۵years. Results: Diabetes was the commonest comorbidity among total of ۵۲ cases. Disease extent-wise, ۱۶, ۲۳ and ۱۳ patients had sino-nasal (SN), rhino-orbital (RO) and rhino-orbito-cerebral (ROC) mucormycosis respectively.  Median cumulative Amphotericin-B administered was ۳.۵gms and ۹۴.۲% of cases underwent surgical debridement depending on the disease extent. With a median follow-up of ۱۸months, ۶۷% of the patients are alive and disease free, ۲% are under treatment and ۲۹% of patients have expired. The mortality rate was ۱۲.۵% in SN, ۳۰.۵% in RO and ۳۸.۵% in ROC mucormycosis. Palatal and orbital involvement is associated with statistically significant mortality risk at one month. Conclusions: Mortality rate in sino-nasal mucormycosis can be significantly curtailed with prompt control of underlying comorbidity, aggressive medical and adequate surgical management.

Keywords:

Amphotericin , Diabetes , Mucormycosis , Sino nasal Mucormycosis , Orbital mucormycosis