Description of cellular receptors in the SARS‐CoV‐۲ infectious disease and potential therapeutic approaches
Publish place: Central Asian Journal of Medical and Pharmaceutical Sciences Innovation، Vol: 2، Issue: 3
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
View: 277
This Paper With 11 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_CAJMPSI-2-3_003
تاریخ نمایه سازی: 11 مرداد 1401
Abstract:
SARS-CoV-۲ or Covid-۱۹ virus is the cause of severe acute respiratory syndrome. This viral pathogen can infect humans mainly via the tract of respiratory. The virus has an RNA genome that encodes two classes of proteins, including enzymatic and structural proteins. One of the structural peptides placed on the virus surface is the spike protein or S protein. This protein, which appears as a glycoprotein on the surface of the virus, binds the virus to the host cell. This glycoprotein detects and binds to the angiotensin-converting enzyme ۲ (ACE۲) molecule on the surface of cell. This protein is then processed by a set of proteases of host cell, thus helping the virus entry into the host cell. Protease peptides including TMPRSS۲, furin, and cathepsins are contributed to this molecular processing. Therefore, inhibition of any of these receptors could be a promising therapeutic approach for the SARS-CoV-۲ treatment. The aim of this study was to define cell receptors in the pathogenicity of Covid-۱۹ virus and to offer probable therapeutic plans based on these receptor’s inhibition.
Keywords:
Authors
Pooya Aavani
Discovery and Translational Research, Biologics Development Sciences, Janssen Biotherapeutics, Spring house, Pennsylvania, USA
Haroon Khan
Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan ۲۳۲۰۰, Khyber Pakhtunkhwa, Pakistan
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :