Association of a Genetic Variant in the Cyclin-Dependent Kinase Inhibitor ۲B with Risk of Pancreatic Cancer

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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JR_RBMB-11-2_017

تاریخ نمایه سازی: 21 مرداد 1401

Abstract:

Background: Pancreatic cancer (PC) is among the most aggressive tumors with a poor prognosis, indicating the need for the identification of a novel prognostic biomarker for risk stratifications. Recent genome-wide association studies have demonstrated common genetic variants in a region on chromosome ۹p۲۱ associated with an increased risk of different malignancies. Methods: In the present study, we explore the possible relationship between genetic variant, rs۱۰۸۱۱۶۶۱, and gene expression of CDKN۲B in ۷۵ pancreatic cancer patients, and ۱۸۸ healthy individuals. DNAs were extracted and genotyping and gene expression were performed by TaqMan real-time PCR and RT-PCR, respectively. Logistic regression was used to assess the association between risk and genotypes, while the significant prognostic variables in the univariate analysis were included in multivariate analyses. Results: The patients with PDAC had a higher frequency of a TT genotype for rs۱۰۸۱۱۶۶۱ than the control group. Also, PDAC patients with dominant genetic model, (TT + TC), was associated with increased risk of developing PDAC (OR= ۱۴.۷۱, ۹۵% CI [۱.۹۶-۱۱۰.۳۵], p= ۰.۰۰۹). Moreover, patients with CC genotype had a higher expression of CDKN۲B, in comparison with TT genotype. Conclusions: Our findings demonstrated that CDKN۲A/B was associated with the risk of developing PDAC, supporting further investigations in the larger and multicenter setting to validate the potential value of this gene as an emerging marker for PDAC.

Authors

Newsha Sardarzade

Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Fatemeh khojasteh-Leylakoohi

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Sedigheh Damavandi

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.

Ghazaleh Khalili-Tanha

Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran & Medical Genetics Research center, Mashhad University of Medical Sciences, Mashhad, Iran.

Mohammad Dashtiahangar

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.

Nima Khalili-Tanha

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.

Amir Avan

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran & Medical Genetics Research center, Mashhad University of Medical Sciences,

Sakineh Amoueian

Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Seyed Mahdi Hassanian

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Habibollah Esmaily

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Majid Khazaei

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Gordon Ferns

Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN۱ ۹PH, UK.

Alireza Khooei

Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Mohsen Aliakbarian

Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

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