The Association between Depression and vitamin D level with disease activity in patient with rheumatoid arthritis
Publish place: Hormozgan Medical Journal، Vol: 22، Issue: 1
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_HMJ-22-1_007
تاریخ نمایه سازی: 30 مرداد 1401
Abstract:
Introduction: Rheumatoid arthritis (RA) is a chronic rheumatologic disease, affecting different aspects of patient life. Although several studies have reported a higher rate of depression among patients with RA, there is still controversy over the underlying risk factors and probable covariates of depression in these individuals. The present study investigated the relationship between disease activity, serum levels of vitamin D, and depression in patients with RA.Methods: In this cross sectional study patients with confirmed RA based on the American College of Rheumatology guidelines entered the study. Disease activity was measured using the Disease Activity Score (DAS). The Hospital Anxiety and Depression Scale (HADS) was also administered to determine the subjects’ level of depression. The Health Assessment Questionnaire (HAQ) was applied for evaluating the subjective disability of the patients in their daily activities. Serum levels of vitamin D, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were also measured.Results: ۶۲ patients were enrolled in the study. Depression was present and possibly present in ۱۲ (۱۹.۴%) and ۱۵ (۲۴.۲%) cases, respectively. According to the results the DAS was inversely associated with vitamin D۳ levels (P<۰.۰۰۱). There were also significant relations between the DAS and scores on both the HAQ and HADS. Moreover, higher levels of vitamin D۳ were related with lower scores on the HAQ and HADS (P=۰.۰۱۸).Conclusion: Higher scores on the HADS were directly associated with lower levels of vitamin D, HAQ score anddisease activity. Nevertheless, no significant association was found with HADS and patients’ sociodemographic characteristics.Targeted approach to psychological aspects and vitamin D levels among patients with RA may have considerable implication for the optimal management of RA.
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Authors
Ali Javadzadeh
Department of Rheumatology, Iran University of Medical Sciences, Tehran, Iran
Anousheh Haghighi
Department of Rheumatology, Iran University of Medical Sciences, Tehran, Iran
Farshad Naserifar
Department of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran
Mohsen Arabi
Department of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran
Atefeh Ghanbari
Department of Psychiatry, Iran University of Medical Sciences, Tehran, Iran
Nahid Kianmehr
Department of Rheumatology, Iran University of Medical Sciences, Tehran, Iran