The Levels of Inflammatory Markers (IL-۶, CRP), Homocysteine and Lipid Profile in Hemodialysis Patients, Isfahan

Background: Cardiovascular disease (CVD) and inflammation areamongthe mostcommoncauses of mortality in dialysis patients.Factors such as chronic inflammation, dyslipidemia and elevated homocysteine levels may underlie the increased risk of CVD.Objectives: This study aimed to investigate levels of inflammatory markers, homocysteine, lipid profile, WBC, and BMI levels inhemodialysis patients compared with the control subjects in Isfahan.Methods: A total of ۳۲ hemodialysis patients and ۳۲ healthy subjects were selected randomly and their serum levels of IL-۶, CRP,homocysteine, and lipid profiles were measured.Results: According to the results, most of the studied hemodialysis patients compared to the healthy subjects had non-normalamounts of IL-۶, CRP, and homocysteine i.e., higher than healthy subjects (P < ۰.۰۵). Cholesterol, HDL, and LDL were significantlylower than the healthy subjects (P < ۰.۰۵), while triglycerides and VLDL levels showed no significant difference (P: ۰.۳۸ > ۰.۰۵). Asignificant difference of BMI was observed between the normal subjects and the patients; thus, this factor in patients was less thanwhat was in the healthy group (P: ۰.۰۰۱ < ۰.۰۵).Conclusions: The results demonstrated that in most patients the levels of factors IL-۶, CRP, and homocysteine were abnormal comparedto the healthy group. In addition, the risk of developing cardiovascular and inflammatory disease as well as dyslipidemia inthese patients is higher than normal.

Keywords:

Hemodialysis , IL-۶ , CRP , Homocysteine , Lipid Profile