Association of serum adiponectin levels with pulmonary artery pressure in maintenance hemodialysis patients

Introduction: Abnormal pulmonary artery pressure (PAP) in hemodialysis patients is associated with significant increase in morbidity and mortality.Objectives: Considering the significance of pulmonary hypertension in hemodialysis patients, a study was designed to assess the association of serum adiponectin levels and PAP in a group of stable hemodialysis patients.Patients and Methods: The study was conducted on a group of non-diabetic hemodialysis patients. The study was carried out in hemodialysis ward of Shahrekord University of Medical Sciences for a period of ۴ months in ۲۰۱۳. The studied patients had a history of dialysis from ۱ to ۲۲ years.Results: In our study, out of ۷۶ hemodialysis patients, ۴۶.۱% were female and ۵۳.۹% were male. The mean PAP in female hemodialysis patients was ۲۹.۷۴ mm Hg, which was about ۹% less than the PAP observed in male hemodialysis patients. Mean adiponectin levels in all the patients, males, and females, respectively, was ۱۰.۵۹, ۱۰.۴۲, and ۱۰.۸۰ μg/mL respectively. In this study a significant and positive relationship between adiponectin levels and PAP in female hemodialysis patients (r = ۰.۳۵, P = ۰.۰۴) was detected.Conclusion: This association requires more investigation on the significant role of adiponectin in hemodialysis patients.

Keywords:

Adiponectin , Pulmonary artery pressure , Hemodialysis , Pulmonary hypertension