Cytotoxic, Antibacterial, and Leishmanicidal Activities of Paullinia pinnata (Linn.) Leaves
Publish place: Avicenna Journal of Medical Biochemistry، Vol: 9، Issue: 2
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_MEBIO-9-2_007
تاریخ نمایه سازی: 30 مرداد 1401
Abstract:
Background: Paullinia pinnata leaves are employed traditionally for the treatment of various ailments
which are of biological origin.
Objectives: The aim of this study was to explore cytotoxic, antibacterial, and antileishmanial properties
of the leaves of Paullinia pinnata using in vitro models.
Methods: Brine shrimp lethality bioassay was used to determine the cytotoxic activity of the methanol
leaf extract of Paullinia pinnata. The activity of the extract against the growth of cultured Leishmania
major (DESTO) promastigotes was used to investigate the leishmanicidal activities. The agar well
diffusion method was used to investigate the antibacterial activity against Salmonella typhi, Pseudomonas
aeruginosa, Shigella flexneri, Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
Results: The methanol leaf extract of P. pinnata had no activity against Artemia salina (brine shrimp)
and L. major. It showed a non-significant activity against E. coli and B. subtilis and no activity against P.
aeruginosa, S. flexneri, S. typhi, and S. aureus.
Conclusion: The methanol leaf extract of P. pinnata did not exhibit any cytotoxic and anti-leishmanial
properties. Moreover, the activity against various species of bacteria was not significant.
Keywords:
Paullinia pinnata leaf extract , Antibacterial activity , Anti-leishmanial activity , Brine shrimp
lethality
Authors
Oluwatoyin Adenike Adeyemo-Salami
Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria- Hussein Ebrahim Jamal (H.E.J.) Research Institute of Chemistry, University of Karachi, Pakistan
Muhammad Iqbal Choudhary
Hussein Ebrahim Jamal (H.E.J.) Research Institute of Chemistry, University of Karachi, Pakistan- Dr. Pajwani Centre for Molecular Medicine and Drug Research, University of Karachi, Pakistan