The Resistance Pattern of Helicobacter Pylori Isolated in the Northeast of Iran, Mashhad

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
View: 126

This Paper With 5 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_RCM-9-1_001

تاریخ نمایه سازی: 31 مرداد 1401

Abstract:

Introduction: Based on serological studies, the prevalence of Helicobacter pylori infection in Iranian adults is up to ۸۰%. Gastritis, peptic ulcer, and gastric adenocarcinoma are common clinical outcomes of this infection in Iran. Since antibiotic resistance patterns of Helicobacter pylori are geographically different, local studies are highly required.Methods: Eighty isolates of Helicobacter pylori were obtained from patients referred to the endoscopy unit of Ghaem Hospital in Mashhad. Demographic features including age, gender, and symptoms were recorded before the sampling. The antibiotic susceptibility patterns of isolates were determined for the five common antibiotics used for the treatment of Helicobacter pylori infection. The agar dilution method was used to evaluate the antibiotic resistance patterns.Results: The patterns of antibiotic resistance were determined, and ۴۱.۲%, ۱۳.۷%, ۸.۷%, ۶.۶%, and ۶.۶% of isolates were resistant to metronidazole, clarithromycin, amoxicillin, tetracycline, and furazolidone, respectively.Conclusion: Our study demonstrates that the overall rate of antibiotic resistance of Helicobacter pylori especially in the case of metronidazole has increased over time. The resistance rates are generally higher in the age range of ۳۰-۶۰ years and in females for the case of metronidazole. This reminds us of the need for a continuous monitoring program of antibiotic susceptibility patterns.

Authors

Mitra Ahadi

Department of Internal medicine, School of medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ali Beheshti Namdar

Department of Internal medicine, School of medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Samaneh Bakhshi

Antimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Elham Mokhtari Amirmajdi

Department of internal medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran

Mohammad Derakhshan

Antimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Atieh Yaghoubi

Antimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

kiarash Ghazvini

Antimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran