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EFFECT OF ENHANCED EXTERNAL COUNTER PULSATION ON PLAS-MA LEVEL OF NITRIC OXIDE AND VASCULAR ENDOTHELIAL GROWTH FACTOR

Publish Year: 1388
Type: Journal paper
Language: English
View: 139

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Document National Code:

JR_RYA-5-2_002

Index date: 24 August 2022

EFFECT OF ENHANCED EXTERNAL COUNTER PULSATION ON PLAS-MA LEVEL OF NITRIC OXIDE AND VASCULAR ENDOTHELIAL GROWTH FACTOR abstract

Abstract    BACKGROUND: Endothelial dysfunction contributes to the manifestation of stable and unstable coronary syndromes in patients with established coronary artery disease (CAD). Enhanced external counterpulsation (EECP) is a noninvasive therapeutic modality for patients with CAD, non responsive to medical and/or surgical treatment. The aim of this research was to determine the long-term effect of EECP on endothelial function via releasing angiogenic factors, NO (nitric oxide) and VEGF (vascular endothelial growth factor), in patients with CAD.    METHODS: The study was performed on 19 consecutive patients with ischemic coronary artery disease. All subjects were treated with EECP 1-h per day, 5 days a week, over 7 weeks (totally 35 h). Serum level of VEGF and nitrite (stable NO metabolite) concentration was measured before EECP, after 24th day, at the end of course (35th day), and at 1 and 3 months after completion of EECP treatment.     RESULTS: After 35 hours of EECP, there was a trend toward increase (31.5 ± 14.7%) in nitrite level compared with baseline (11.12±3.17vs 9.65±1.36mg/L) but it wasn’t significant. Results of 1and 3 month follow-up after treatment showed that, the nitrite levels significantly increased compared with the baseline. During the course of EECP therapy, plasma VEGF levels increased progressively .Significant increase in plasma levels of VEGF were began from second sampling session of our study (24th day) and reached to maximum 3 month after EECP therapy.    CONCLUSION: In this prospective study that assessed the effects of EECP on plasma nitrite and VEGF levels, it has been demonstrated that EECP progressively increases nitrite and VEGF levels during the course of therapy. These significant changes continued 3 months after EECP therapy.

EFFECT OF ENHANCED EXTERNAL COUNTER PULSATION ON PLAS-MA LEVEL OF NITRIC OXIDE AND VASCULAR ENDOTHELIAL GROWTH FACTOR authors

Masoud Pourmoghadas

MD, Professor of Cardiology, Isfahan University of Medical Sciences, Isfahan.

Hajar Nourmohamamadi

MD, Student of medicine, Isfahan University of Medical Sciences, Isfahan.

Faezeh Tabesh

Student of Medicine, Isfahan University of Medical Sciences, Isfahan.

Shaghayegh Haghjoo

MD, PhD, Assistant professor, Applied Physiology Research Center, Department of Physiology, Isfahan University Of Medical Sciences, Isfahan.

Elham Tabesh

Student of Medicine, Isfahan University of Medical Sciences, Isfahan.