Microwave Synthesis Schiff Base from Drug and ۱,۱۰-Phenanthroline/۸-Hydroxyquinoline as a Co-ligand with Complexes: Cytotoxic, Antimicrobial, and DNA Interaction Efficacy

Trimethoprim and benzophenone are mixed to form the Schiff-base of the N۲O donor ligand. Various spectroscopies are used to describe the ligand. Numerous new mixed ligand complexes of two ligands are produced with Ni(II), Co(II), and Cu(II) ions, where Schiff base = (L۱) (۱,۱۰-Phen) and deprotonated (۸-HQ = (L۲).(MO)metal oxide is the last product of heat breakdown for specific complexes, according to research. Additionally, water molecules that are linked to complexes are found to be coordinated or crystalline by thermal gravimetric measurement (TGA). The Schiff base preparation technique yields complexes of Co(II), Ni(II) and Cu(II) with octahedral geometry (for ۱,۱۰-PhenIn addition, antimicrobialmixed ligand complexes have been tested against the pathogenic strains of bacteria and fungus types, whichareEscherichia Coli, Bacillus subtilis ,EterobacternandStaphylococcus aureus,F.solani and C.cucurbitacin.A۵۴۹, HaCaT and MCF-۷ anticancer cell lines have been investigated. The outstanding result of mixed Cu(II) complexes was highlighted.

Keywords:

Schiff base , complexes , Cytotoxic , MCF-۷ , Antimicrobial