Myo-inositol effect on pregnancy outcomes in infertile women undergoing in vitro fertilization/intracytoplasmic sperm injection: A double-blind RCT

Background: Myo-inositol is an intracellular mediator which is involved in various aspects of reproduction in women. Objective: This study aimed to evaluate the impact of Myo-inositol on the outcomes of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles in infertile women. Materials and Methods: This double-blind randomized controlled trial was conducted on ۷۰ infertile women referred to the Infertility Treatment Center, Besat hospital, Sanandaj, Iran from May ۲۰۱۹ to September ۲۰۱۹ for IVF/ICSI cycles. The participants were randomly divided into ۲ intervention (n = ۳۶) and control (n = ۳۴) groups. The intervention group received ۲۰۰۰ mg of Myo-inositol and ۲۰۰ mcg folic acid twice a day for ۲ months and the control group received ۲۰۰ mcg of folic acid twice a day for ۲ months in the IVF/ICSI cycles (from the third day of cycle until the end of the second month). Finally, the number of oocytes, the quality of embryos, and the IVF/ICSI outcomes were compared between the ۲ groups. Results: The mean numbers of oocytes, MII oocytes, and ۲ pronuclear embryos were significantly higher in the intervention group than the control group. Also, the clinical pregnancy and live birth rates in the intervention group were significantly higher than in the controls (p = ۰.۰۴). Conclusion: The administration of Myo-inositol may increase clinical pregnancy and live birth rates by increasing the number of total and meiosis II oocytes in infertile women undergoing IVF/ICSI.

Keywords:

Infertility , In vitro fertilization , Intracytoplasmic sperm injection , Myo-inositol. , ناباروری , لقاح آزمایشگاهی , تزریق داخل سیتوپلاسمی اسپرم , میواینوزیتول.