Effect of n-۶ and n-۳ fatty acids on expression of pro-inflammatory cytokines in lambs vaccinated against foot and mouth disease virus
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_KLST-10-1_007
تاریخ نمایه سازی: 9 مهر 1401
Abstract:
The current study was aim to the effects of n-۶ and n-۳ polyunsaturated fatty acids (PUFA, or palmitic acid sources) on expression of pro-inflammatory cytokines in lambs vaccinated against foot and mouth disease (FMD) virus. A total of fifteen Sangsari male lambs with an age of ۶ ± ۱ months and body weight of ۴۲ ± ۱ kg were randomly assigned to one of three experimental treatments as follows: ۱) PO: received calcium soap of palm oil fatty acid (FA) in the diet as source of palmitic acid (۱۶:۰), ۲) SO: received calcium soap of sunflower oil FAs in the diet as source of linoleic acid (n-۶ ۱۸:۲) and ۳) LO: received calcium soap of linseed oil FA in the diet as source of α-linolenic acid (n-۳ ۱۸:۳). The lambs were offered an iso-energetic and iso-nitrogenous diet for ۲۸ days (including ۲۱ days of adaptation and ۷ days of sampling). The lambs were individually housed and had access to water ad libitum. The expression of interleukin-۱β (IL-۱β) mRNA was lower in LO when compared with PO and SO (P<۰.۰۵). The expression of tumor necrosis factor-α (TNFα) mRNA was higher in PO when compared with SO and LO and the lowest expression of TNFα mRNA was measured in LO (P<۰.۰۵). Lower concentrations of serum cholesterol and triglyceride (TG) were measured in vaccinated lambs on LO diet when compared with vaccinated lambs on palmitic FA diet (P<۰.۰۵). There was no significant difference between SO and LO groups in serum cholesterol or TG levels. There were no significant differences between treatments (P>۰.۰۵) in serum level of total proteins and albumin. The findings from the current study showed feeding α-linolenic acid diet following vaccination against FMD resulted in a decrease in serum levels of cholesterol and TG due to higher n-۳ PUFA intake and suppressed the pro-inflammatory cytokine expression (IL-۱ and TNFα).
Keywords:
Acute-phase proteins , Alpha-linolenic acid , Conjugated linoleic acid , Foot and Mouth Disease , Linseed
Authors
Ali Ghorbani
Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Ali Asghar Sadeghi
Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Parvin Shawrang
Agriculture Nuclear Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, Iran.
Mohammad Chamani
Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Farhad Forodi
Department of Animal Science, Pishva-Varamin Branch, Islamic Azad University, Varamin, Iran.
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