Anticancer Effects of Caffeic Acid on A۵۴۹ Non-small CellLung Cancer Cells
Publish place: Twenty-third International Congress of Microbiology of Iran
Publish Year: 1401
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
MEDISM23_309
تاریخ نمایه سازی: 16 مهر 1401
Abstract:
Background and Aim : Cancer is a major threat to human health and a global problem, and lungcancer is the most common type of malignant tumor. Caffeic acid is one of the known phenoliccompounds. The beneficial effects of Caffeic acid, including its anti-inflammatory, anti-viral,immune-boosting, antioxidant and carcinostatic and anticarcinogenic properties have beenconfirmed in several studies. The aim of this study was to evaluate the induction of apoptosis inlung cancer cells by Caffeic acid (obtained from propolis).Methods : Cultured lung cancer cell lines (A۵۴۹) were treated with Caffeic acid then the treatedcells were examined by flow cytometry after preparation.Results : The results showed that Caffeic acid has effective roles in inducing apoptosis and hascaused significant changes in the percentage of living cells and the percentage of cells in the earlyand late phase of apoptosis.Conclusion : Caffeic acid has significant apoptotic effects on lung epithelial cancer cells and hasan effective role in inhibiting lung cancer cells, so it can be considered as an effective substancein the treatment of cancer.
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Authors
Raham Mojibi
Mycology research center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Ali reza Khosravi
Mycology research center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Jalil Mehrzad
Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran