A systematic review study on Role of long non-coding RNAs(lncRNAs) in tuberculosis

Background and Aim : Mycobacterium tuberculosis is the bacterial agent that causestuberculosis. In this bacterium long non-coding RNAs (lncRNA) can positively and negativelyalter the expression of various genes through various mechanisms such as activating transcriptionfactors or binding to DNA targets of the chromatin complex. The purpose of current study was areview of the lncRNAs in M.tuberculosisMethods : We searched with the keywords lncRNAs, lncRNA, Long ncRNA, LincRNAs, LongncRNA, Long noncoding RNA, Tuberclosis ,TB, Pulmonary Tuberculosis ،Pulmonary TB,Mycobacterium tuberculosis in PubMed, Web of Science Direct, Scopus, Scientific InformationDatabases, and Google scholarResults : A total of ۱۲۴ articles were found in Pub Med, Web of Science Direct, Scopus, ScientificInformation Databases, and Google scholar, of which ۲۰ articles were shared between thedatabases. In the revision of title and abstract, ۸۴ articles were excluded from our study. Finally,۱۹ articles were included in our study, which included ۴۴۴۴ patients with tuberculosis. All studieswere performed in China using the qRT-PCR method. We also studied the relationship betweenLNCRNAs in terms of biomarkers, therapeutic goals, drug side effects, and clinical features oftuberculosis.Conclusion : The results of present study showed there is an acceptable association betweenlncRNA and SNP with tuberculosis and M.tuberculosis. Also, these regulatory factors play animportant role as diagnostic biomarkers and the development of new therapies

Keywords:

Mycobacterium tuberculosis , long non-coding RNAs (lncRNA) , systematicreview , biomarker , TB