Quality Control and Testing Evaluation of Various Metoprolol Tartrate (۵۰ mg) Tablets Available in Iraq Market

This study was done to assess the effectiveness of commercially available tablets of metoprolol tartrate (۵۰ mg). The specified tablets were manufactured in different companies and existed in the Iraqi market. The quality control tests were performed on various batches of film-coated tablets containing metoprolol tartrate. Weight variations, friability, hardness, drug content, disintegration time, and drug dissolution assay were among the tests conducted. The results of these tests were compared with the specifications of the USP Pharmacopeia. The obtained data in this research showed that all tablets of metoprolol tartrate from different products followed the USP limitation, the hardness was (۷.۴۷-۹.۸۷ kg/cm۲), the drug content result was (۹۳.۴-۹۹.۴%) with in the USP limitation. The result of disintegration time and weight uniformity test were acceptable with pharmacopeia limitation, the in vitro release profile for all different batches was more than ۸۵% in ۳۰ minutes. This study clearly showed that all of the marketed batches of the metoprolol tartrate tablets were in a good agreement with the standards limitation of the USP pharmacopeia for the quality control tests.

Keywords:

Metoprolol tartrate , quality control test , oral dosage form , Dissolution , Hardness