New Formulation of Dry Powder Inhaler Capsules
Publish place: Sixth National Conference on Innovation and Technology of Biological Sciences Iranian Chemistry
Publish Year: 1401
نوع سند: مقاله کنفرانسی
زبان: English
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BCBCN06_005
تاریخ نمایه سازی: 19 مهر 1401
Abstract:
The Dry Powder Inhaler (DPI) is the favored device to remedy a variety of diseases. In this regard, we investigated the preparation and development of a new formulation for DPI capsules. We studied the effect of polyethylene glycol (PEG) percentages as a plasticizer on the brittleness, and particle release of manufactured DPI capsules. The results showed that the lower molecular weight of PEGs presented the better plasticizing capability of gelatin. PEG۴۰۰ increased the capsule flexibility for a longer time and its stability under environmental conditions in gelatin capsule formulation, likewise, no particle release was observed in the gelatin/PEG capsule. The capsules were evaluated in terms of loss on drying (LOD), surface morphology, roughness, and puncture type. Besides, gelatin/PEG capsules have no particles due to the smooth surface after the punching process. The as-produced capsules are not blocked again after punching, allowing the patient to take the drug completely. In fact, the present research provided substantial insight regarding the development of DPI formulation in capsule investigations on an industrial scale.
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Authors
Ramin Ramezani Kalmer
Iran Gelatin capsule mfg Co, ۳۳۵۱۷۷۳۴۱۵, Tehran, Iran.
Mohsen Mohammadi Haddadan
Iran Gelatin capsule mfg Co, ۳۳۵۱۷۷۳۴۱۵, Tehran, Iran.
Maryam Azizi
Iran Gelatin capsule mfg Co, ۳۳۵۱۷۷۳۴۱۵, Tehran, Iran.
Hamed Ramezanalizadeh
Iran Gelatin capsule mfg Co, ۳۳۵۱۷۷۳۴۱۵, Tehran, Iran.
Mojgan Ghanbari
Iran Gelatin capsule mfg Co, ۳۳۵۱۷۷۳۴۱۵, Tehran, Iran.