The effects of betulinic acid chronic administration on the motor, non-motor behaviors, and globus pallidus local field potential power in a rat model of hemiparkinsonism
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-25-11_010
تاریخ نمایه سازی: 30 مهر 1401
Abstract:
Objective(s): Parkinson’s disease (PD) is a neurodegenerative disorder involving the central nervous system associated with motor and non-motor impairments. Betulinic acid (BA) is a natural substance considered an antioxidative agent. This study aimed to investigate the therapeutic potential of BA on motor dysfunctions and globus pallidus (GP) local EEG power in a ۶-hydroxydopamine (۶-OHDA)-induced rat model of hemiparkinsonism.Materials and Methods: Adult Wistar rats were categorized into different groups, containing; Sham, PD, and treated groups including different doses of BA (۰.۵, ۵, and ۱۰ mg/kg, IP), and L-dopa (۲۰ mg/kg, PO, as positive control). The lesion was induced in the right medial forebrain bundle by injection of ۶-OHDA (۲۰ µg/kg). The treatment was begun just after the approved rotational test induced by apomorphine, ۱۴ days after ۶-OHDA administration. Motor behaviors such as catalepsy and stride-length and non-motor responses, including GP local EEG, were then assessed. Also, the levels of GSH, catalase, and concentration of dopamine in the brain tissue were measured. Results: Treatment of hemiparkinsonian rats with BA significantly improved catalepsy and stride-length (P<۰.۰۰۱ and P<۰.۰۱, respectively) and GP frequency bands’ powers (P<۰.۰۰۱). Moreover, the activities of GSH (P<۰.۰۰۱), catalase (P<۰.۰۰۱), and the concentration of dopamine (P<۰.۰۰۱) in the brain were increased.Conclusion: Current results proved the potent ability of BA to scavenge free radicals and to remove oxidative agents in the brain tissue. This natural product could be considered a possible therapeutic compound for motor and non-motor disorders in PD.
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Authors
Maryam Abrishamdar
Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishpur University of Medical Sciences, Ahvaz, Iran
Alireza Sarkaki
Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishpur University of Medical Sciences, Ahvaz, Iran
Yaghoob Farbood
Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishpur University of Medical Sciences, Ahvaz, Iran
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