Clinicopathologic Features and Survival Analysis of Non-metastatic Breast Cancer Patients in Guatemala

Background: Breast cancer (BC) is a leading cause of cancer related deathworldwide. Unfortunately, data concerning clinicopathologic features of thismalignancy in non-developed countries is scarce. This study aims to characterize acohort of Guatemalan female patients with non-metastatic BC and to determinerisk factors for overall survival (OS). Methods: We retrieved data on consecutive patients from the InstitutoGuatemalteco de Seguridad Social that were treated from 2008 to 2014. Clinicalfeatures and long-term outcomes were retrieved from medical records. Univariateand multivariate Cox regression analyses were conducted to identify variablesassociated with OS. Results: 954 BC patients were identified during the time frame. A total of 436women (46%) were younger than 50 years old. BC molecular subtypes categorized537 patients (56.3%) with luminal A disease, 186 (19.5%) patients with triplenegative tumors, 153 cases (16.1%) with HER-2 enriched tumors, and 78 patients(8.2%) with luminal B tumors. Clinical stage at presentation was stage I: 4.7%(n=45); stage II: 48.1% (n=459), and stage III: 47.2% (n=450). The overall 5-yearsurvival rate was 75.2% (95% Confidence Interval: 72.0–78.3). In the multivariateanalysis clinical stage, triple negative tumors and HER2 enriched tumors wereindependently associated with poor survival. Conclusion: The majority of patients with non-metastatic BC are diagnosedwith advanced disease and many of them are younger than 50 years old. OS in thiscohort of Guatemalan patients is lower than that reported in developed countries.

Clinicopathologic Features and Survival Analysis of Non-metastatic Breast Cancer Patients in Guatemala Keywords:

Brest cancer , Guatmala , survival