Prognostic Value of Androgen Receptor in Triple Negative Breast Cancer of Iranian Patients in Yazd Region

Background: Triple negative breast cancer (TNBC) is a heterogeneous diseasegroup with a higher recurrence risk and poorer prognosis. In this study, we aimed toinvestigate the frequency and prognostic value of androgen receptor (AR)expression in tissues of TNBC patients.Methods: In this study a total of ۶۰ TNBC patients treated between ۲۰۱۱ - ۲۰۱۶in Shahid Sadoughi and Mortaz Hospital were included and their medical recordswere analyze. The available paraffin blocks were assessed immunohistochemicallyto determine AR expression. Tumors with ≥۱۰% nuclear staining were consideredAR-positive, while the ones with <۱۰% staining were considered AR-negative. Theassociation between AR expression, and clinical-pathologic characteristics andprognosis in TNBC was analyzed.Results: The result showed that AR expression in TBNC correlated with highrisk of recurrence but no significant correlation with the age, grade, tumor size,lymph node status, type of diagnosis, tumor location, and Ki-۶۷ level wasobserved. Positive immunoreactivity for AR was observed in ۱۹ out of ۶۰ (۱۱%)specimens. No correlation was observed between the AR expression and the age,grade, tumor size, lymph node status, type of diagnosis, tumor location, and Ki-۶۷level. The AR-positive patients exhibited high risk of recurrence (P=۰.۰۱۶) anddeath (P=۰.۰۱۵) in comparison with the AR-negative patients.Concusions: AR may not be a suitable biomarker and treatment target for theIranian Yazd patients with TNBC.

Keywords:

Androgen receptor (AR) , TNBC , Immunohistochemistry