A New Potentiomertic Sensor for a Preventing Alzheimer’s Disease Drug Based on Nano-Silver Modified Carbon Paste Electrode

Due to the importance of vitamin B۶ (VB۶) drug for human health, especially in the treatment of Alzheimer's disease, it is useful to develop new, simple, cheap and rapid methods for the determination of this compound. A high linear range and a sensitive potentiometric sensor for VB۶ based on carbon paste electrode (CPE) modified with synthesized silver nanoparticles by co-precipitation method were prepared. The sensor fully characterized in terms of distinctive nanoparticles quality, electrode composition, and usable pH range. Under optimal conditions, a linear calibration curve with range ۱×۱۰-۶ to ۱×۱۰-۲mol L−۱ and a detection limit of ۴.۸۴×۱۰-۷molL−۱ was obtained for VB۶ determinations. The research introduces the design and construction of the nanocomposite modified CPE for simple and low-cost determination of VB۶ in pharmaceutical formulation. Validation of the method indicates the suitability of the sensor for application in quantity control analysis of VB۶ drug in pharmaceutical formulation preparations.

Keywords:

Potentiometric Sensor , Modified Carbon Paste Electrode , Vitamin B۶ , Silver NPs