Fibrinogen and Fibrin Degradation Products’ Levels in Cardiopulmonary Bypass with Mild-Hypothermia versus Normothermia

Background: Coagulation cascades are activated during Cardiopulmonary Bypass (CPB) and their proper monitoring and maintenance determine the outcomes of operation to a big extent. Here, we assessed serum fibrinogen and Fibrin Degradation Products (FDP) in adult patients undergoing CABG with using CPB, either with hypothermia or normothermia.Materials and Methods: In a cross-sectional study, ۸۰ adult patients’ candidate for elective CABG were randomly assigned into two groups: hypothermia and normothermia to assess fibrinogen and FDP, perioperatively.Results: Patients included ۳۲ men (۸۰%) in the hypothermia group and ۲۶ men (۶۰%) in the normothermia with the mean age of ۶۱.۴۳ ± ۱۲.۶۴ years. The mean temperature in the hypothermia group was ۳۲.۳۳ ± ۱.۴۴ and ۳۵.۳۳ ± ۰.۷۱ in the normothermic group. Differences in fibrinogen levels between the two groups were not significant (Fib before CPB, P=۰.۸۹۳, and Fib after declamping, P=۰.۰۵۷). The serum level of FDP before and during CPB was not significantly different in hypothermia and normothermia groups (P=۰.۴۱۲, P=۰.۷۷۸, respectively).Conclusion: During cardiac surgery in hypothermia and normothermia conditions rate of fibrinogen decreased ۲۵% after declamping in each group; this decrease seems to be due to hemodilution. FDP levels were similar in both groups.

Keywords:

Fibrinogen , Fibrin Degradation Products , Hypothermia , Cardiopulmonary bypass