Taguchi design optimization of curcumin loading in mesoporous silica nanoparticles with variable particle and pore sizes
Publish place: Trends in Pharmaceutical Sciences، Vol: 8، Issue: 3
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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تاریخ نمایه سازی: 24 آبان 1401
Abstract:
Mesoporous silica nanoparticles (MSNs) have received a lot of attention due to their wide range of applications in the delivery of poorly soluble phytochemicals like curcumin (CUR). Given that pore diameter and particle size determine the specific surface area, as well as drug loading in mesoporous nanoparticles, in the present study, we developed MSNs with varying pore sizes to investigate their effects on CUR loading. Dynamic light scattering (DLS), field-emission- scanning electron microscopy (FE-SEM), and Brunauer-Emmett-Teller (BET) analyses were used to characterize the MSNs. CUR was loaded into MSNs using solvent evaporation method, and the drug loading was determined using UV spectroscopy. Results revealed that the MSN synthesis condition had a significant effect on pore size and particle diameter. According to FE-SEM micrographs, MSNs had a nearly spherical shape. DLS results indicated particle sizes ranging from ۲۵ to ۱۰۰ nm. According to the BET findings, pore size and specific surface area varied in range of ۴ - ۸ nm and of ۵۷۰ - ۱۱۸۰ m۲/g, respectively. In addition, CUR loading efficiency and loaded amount were ۷۵% and ۳۳% in optimal conditions, respectively. These findings supported the use of MSNs to load and deliver CUR as a poorly soluble drug in a variety of pathophysiological conditions. Keywords: Mesoporous silica nanoparticles, Pore size, Particle size, Surface area, Drug loading, Curcumin. Please cite this article as: Mina Shafiee, Samira Sadat Abolmaali, Mozhgan Abedanzadeh, Ali Mohammad Tamaddon. Taguchi design optimization of curcumin loading in mesoporous silica nanoparticles with variable particle and pore sizes. Trends in Pharmaceutical Sciences. ۲۰۲۲;۸(۳):۱۵۵-۱۶۴. doi: ۱۰.۳۰۴۷۶/TIPS.۲۰۲۲.۹۵۶۴۶.۱۱۵۰
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Authors
Mina Shafiee
Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran.
Samira Sadat Abolmaali
Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran.
Mozhgan Abedanzadeh
Pharmaceutical Nanotechnology Department, Shiraz School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Alimohammad Tammadon
Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran.
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