Taguchi design optimization of curcumin loading in mesoporous silica nanoparticles with variable particle and pore sizes

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
View: 26

This Paper With 10 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_TIPS-8-3_004

تاریخ نمایه سازی: 24 آبان 1401

Abstract:

Mesoporous silica nanoparticles (MSNs) have received a lot of attention due to their wide range of applications in the delivery of poorly soluble phytochemicals like curcumin (CUR). Given that pore diameter and particle size determine the specific surface area, as well as drug loading in mesoporous nanoparticles, in the present study, we developed MSNs with varying pore sizes to investigate their effects on CUR loading. Dynamic light scattering (DLS), field-emission- scanning electron microscopy (FE-SEM), and Brunauer-Emmett-Teller (BET) analyses were used to characterize the MSNs. CUR was loaded into MSNs using solvent evaporation method, and the drug loading was determined using UV spectroscopy. Results revealed that the MSN synthesis condition had a significant effect on pore size and particle diameter. According to FE-SEM micrographs, MSNs had a nearly spherical shape. DLS results indicated particle sizes ranging from ۲۵ to ۱۰۰ nm. According to the BET findings, pore size and specific surface area varied in range of ۴ - ۸ nm and of ۵۷۰ - ۱۱۸۰ m۲/g, respectively. In addition, CUR loading efficiency and loaded amount were ۷۵% and ۳۳% in optimal conditions, respectively. These findings supported the use of MSNs to load and deliver CUR as a poorly soluble drug in a variety of pathophysiological conditions. Keywords: Mesoporous silica nanoparticles, Pore size, Particle size, Surface area, Drug loading, Curcumin. Please cite this article as: Mina Shafiee, Samira Sadat Abolmaali, Mozhgan Abedanzadeh, Ali Mohammad Tamaddon. Taguchi design optimization of curcumin loading in mesoporous silica nanoparticles with variable particle and pore sizes. Trends in Pharmaceutical Sciences. ۲۰۲۲;۸(۳):۱۵۵-۱۶۴. doi: ۱۰.۳۰۴۷۶/TIPS.۲۰۲۲.۹۵۶۴۶.۱۱۵۰

Authors

Mina Shafiee

Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran.

Samira Sadat Abolmaali

Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran.

Mozhgan Abedanzadeh

Pharmaceutical Nanotechnology Department, Shiraz School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Alimohammad Tammadon

Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran.

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Yallapu MM, Nagesh PK, Jaggi M, Chauhan SC. Therapeutic Applications ...
  • Karewicz A, Bielska D, Gzyl-Malcher B, Kepczynski M, Lach R, ...
  • Abedanzadeh, M., et al., Curcumin loaded polymeric micelles of variable ...
  • Gong C, Wu Q, Wang Y, Zhang D, Luo F, ...
  • Parvathy, K., P. Negi, and P. Srinivas, Curcumin–amino acid conjugates: ...
  • Nandiyanto ABD, Kim S-G, Iskandar F, Okuyama K. Synthesis of ...
  • Kao K, Mou C. Pore-expanded mesoporous silica nanoparticles with alkanes/ethanol ...
  • Kilpeläinen M, Riikonen J, Vlasova MA, Huotari A, Lehto VP, ...
  • Chen JF, Ding HM, Wang JX, Shao L. Preparation and ...
  • Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy ...
  • Sachs-Barrable K, Lee SD, Wasan EK, Thornton SJ, Wasan KM. ...
  • Dinda AK, Prashant CK, Naqvi S, Unnithan J, Samim M, ...
  • Kim S, Stébé M,a Blina J, Pasc A. pH-controlled delivery ...
  • Patra, D. and F. Sleem. A new method for pH ...
  • Li N, Wang Z, Zhang Y, Zhang K, Xie J, ...
  • Lv Y, Li J, Chen H, Bai Y, Zhang L. ...
  • Radhakrishnan K, Tripathy J, Datey,bc Chakravortty A.D, RaichurA.M. Mesoporous silica–chondroitin ...
  • Sun X, Wang N, Yang LY, Ouyang XK, Huang F. ...
  • Xu X, Lü S, Gao C, Feng C, Wu C, ...
  • Zhang Y, Zhi Z, Jiang T, Zhang J, Wang Z, ...
  • Shafiee M, Abolmaali S, Abedanzadeh M, Abedi M, Tamaddon A. ...
  • Shafiee M, Abolmaali SS, Tamaddon AM, Abedanzadeh M, Abedi M. ...
  • Sreelola V, Sailaja AK, Pharmacy M. Preparation and characterisation of ...
  • Freidus LG, Kumar P, Marimuthu T, Pradeep P, Choonara YE. ...
  • Taebnia N, Morshedi D, Yaghmaei S, Aliakbari F, Rahimi F, ...
  • Basavarajappa S, Chandramohan G, Davim JP. Application of Taguchi techniques ...
  • Wang Y, Shan Y, Chen KZ, Gao L. Mesoporous Silica ...
  • Abdous B, Sajjadi SM, Ma’mani L. β-Cyclodextrin modified mesoporous silica ...
  • Bolouki A, Rashidi L, Vasheghani-Farahani E, Piravi-Vanak Z. Study of ...
  • Daryasari MP, Akhgar MR, Mamashli F, Bigdeli B, Khoobi M. ...
  • Kuang G, Zhang Q, He S, Liu Y. Curcumin-loaded PEGylated ...
  • Ma'mani L, Nikzad S, Kheiri-Manjili H, Al-Musawi S, Saeedi M, ...
  • Elbialy NS, Aboushoushah SF, Sofi BF, Noorwali A. Multifunctional curcumin-loaded ...
  • Ghosh S, Dutta S, Sarkar A, Kundu M, Sil PC. ...
  • Kong ZL, Kuo HP, Johnson A, Wu LC, Chang KLB. ...
  • Yadav YC, Pattnaik S, Swain K. Curcumin loaded mesoporous silica ...
  • Harini L, Srivastava S, Gnanakumar GP, Karthikeyan B, Ross C, ...
  • Mohebian Z, Babazadeh M, Zarghami N. In Vitro Efficacy of ...
  • Mondal S, Ghosh S, Moulik SP. Stability of curcumin in ...
  • Abedi M, Abolmaali SS, Abedanzadeh M, Borandeh S, Samani SM, ...
  • Abedi M, Abolmaali SS, Abedanzadeh M, Farjadian F, Mohammadi Samani ...
  • Soleimanpour M, Tamaddon AM, Kadivar M, Abolmaali SS, Shekarchizadeh H. ...
  • Mashayekhi S, Rasoulpoor S, Shabani S, Esmaeilizadeh N, Serati-Nouri H, ...
  • نمایش کامل مراجع