Antihepatotoxic Effect of Eruca sativa Extracts on Alcohol Induced Liver Injury in Rats

Objective: Food derived antioxidants have a special property for long term use as chemopreventive factor in disease states such as alcoholic liver diseases and hepatitis. This research decided to assess the property of several Eruca Sativa Mill extract in ethanol induced liver injury in animals. Material and Methods: ۳۰ rats were divided into four groups included treated groups with E. Sativa extracts (Water and methanolic), prophylactic and control. Oxidants/antioxidants profile, lipid profile and serum liver functions tests were done. Results: The finding revealed that extracts of E. Sativa decrease the alcoholic liver injury. In addition, the extracts of E. sativa may exert their prophylactic and cure role against ethanol oxidative stress by enhancing the antioxidant enzymes and antioxidant molecules levels. Conclusion: Totally, this research proofed that the E. sativa leaves water extract is better than methanolic extract in decreasing alcoholic liver injury.

Keywords:

Eruca sativa , Antihepatotoxic , Induced Liver , alcoholic liver diseases