Synthesis of ۳-substituted Indoles through Yonemitsu Reaction with Copper Benzene-۱,۳,۵-tricarboxylate acid Catalyst
Publish place: Materials Chemistry Horizons، Vol: 1، Issue: 3
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
View: 168
This Paper With 8 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_MCH-1-3_002
تاریخ نمایه سازی: 30 آبان 1401
Abstract:
۳-substituted indole derivatives as a key intermediate for the synthesis of complex indole alkaloids have been synthesized by Yonemitsu condensation reaction between indole, dimedone, and benzaldehyde. This reaction was carried out using copper benzene-۱,۳,۵-trioxylate acid catalyst for the first time. In addition to its acidic properties, the aforementioned catalyst has a ۳D network, and the existence of these holes can help to advance the reaction. This reaction proceeds smoothly and has achieved good yields (۸۰-۹۰%) by using water as a green solvent at ۶۰°C. The investigations show that the electron-withdrawing groups on the aldehyde compound perform the reaction at a higher speed, which is completely consistent with the presented mechanism and the presence of the carbocation. This modified reaction has numerous advantages, including high efficiency, short reaction time, low reaction temperature, and the use of water as a green solvent.
Keywords:
Authors
Fariba Heidarizadeh
Department of Chemistry, Shahid Chamran University of Ahvaz, Ahvaz, ۶۱۳۵۷۴۳۱۶۹, Iran
Ehsan Rahimi
Department of Chemistry, Shahid Chamran University of Ahvaz, Ahvaz, ۶۱۳۵۷۴۳۱۶۹, Iran