Sleep pattern in women with polycystic ovary syndrome

Background: The cycle of sleep/ wake, especially in humans, is one of the special abilities that are considered among the higher function of the brain. The main activities of life are regulated by energy balance. Part of this energy balance is done by sleep, which is a good opportunity and time to rebuild the chemicals of the brain and is very important in establishing recognition between the organism and its environment. The aim of this research is to investigate the sleep pattern in PCO patients, which was done by questionnaire and biochemical tests. Methods: In the present case-control study, the serum levels of stress neurohormones, beta-endorphin, sleep, and progesterone were measured in 77 patients with polycystic ovaries and 97 people in the control group, which are healthy women. Sleep patterns were investigated by the Pittsburgh PSQI sleep quality questionnaire in two groups.Results: The serum level of the stress hormones adrenaline and noradrenaline in the PCO group who went to sleep earlier (before 11:00 p.m.) is 3.88 ± 2.54 significantly lower than those in the same group who went to sleep later (after 11:00 p.m.). 6.43± 4.71 (P = 0.041). The beta-endorphin hormone was lower in the PCO group than in the control group (P = 0.001). Melatonin was also lower in the PCO group than in the control group (P = 0.031).Conclusion: Our results showed that patients who sleep late at night and wake up late in the morning have significant changes in the levels of adrenaline, noradrenaline, melatonin, and beta-endorphin neurohormones.