Vitamin D Supplementation could improve inflammation and antioxidant markers in vitamin D deficient students with premenstrual syndrome

Objective: Premenstrual syndrome is a common disorder in reproductive age, which includes a wide range of symptoms that have a significant negative impact on women's quality of life. The aim of this study was to determine the effect of vitamin D supplementation on inflammatory and antioxidant indices of premenstrual syndrome (PMS) in vitamin D‐deficient students. Methods: A total of ۴۴ vitamin D‐deficient PMS students participated in this randomized, parallel, placebo-controlled, double-blind clinical trial study. Participants were randomly assigned to receive either ۵۰ ۰۰۰ IU vitamin D۳ or a placebo pearl fortnightly for ۴ months. At the baseline and in the last ۲ months of intervention, participants were asked to complete the PMS Daily Symptoms Rating form along with taking the pearls. Blood samples were collected at the baseline and the end of the study in order to assess serum levels of ۲۵(OH)D۳, Interleukine۱۰ and ۱۲(IL-۱۰, IL-۱۲) and total antioxidant capacity (TAC). Results: The mean serum ۲۵-hydroxyvitamin D levels increased by ۴۷% after ۴ months of supplementation with vitamin D and reached a normal level of ۳۷.۴۰ ng / ml. In the intervention group, after the end of study, serum levels of IL-۱۰, IL-۱۲ were ۱۸.۷ and ۶۰.۴۱ percent respectively (P <۰.۰۰۱ and P = ۰.۰۰۱ respectively) and serum TAC increased by ۶۷.۶۶% (P <۰.۰۰۱) Therefore, after the study, there was a significant difference in serum levels of IL-۱۰, Il-۱۲ and TAC between the two intervention and control groups. Also, the comparison of mean score of the total PMS symptoms showed a significant improvement in the intervention group (P <۰.۰۰۱). Conclusions. Vitamin D seems to be a safe and effective option to improve psychological symptoms, inflammatory and antioxidant indices of premenstrual syndrome (PMS) in vitamin D‐deficient students. the effect of vitamin D and placebo on the

Keywords:

vitamin D , Premenstrual syndrome (PMS) , antioxidant , inflammation