The effect of Trachyspermum optical aqueous extract on blood Homeostasis

T. capsicum from medicinal herbs is considered as a rich source of thymol with healing properties. Enzymatic coagulation factors stem from the liver. In the present study, ۴۸ adult Wistar male rats were selected and divided randiomly into six groups, including control,witness, and ۴ experimental groups. Bleeding time (BT), clotting time (CT), prothrombin time (PT) and activated partial thromboplastin time (PTT) were measured by wounding on the ears, slide and coagulometric methods, using the Dade Behring kits and four-channel-coagulometer, respectively. The resulting values were then analyzed. The results of the measurement of prothrombin time (PT) showed no statistically significant differences in the groups at P≤ ۰.۰۵ level. But the measure of activated partial thromboplastin time (PTT) revealed a significant difference between experimental group ۲ and the control group. The average time of clotting represented a significant statistical difference in all experimental groups compared to the control group. Moreover, there was statistically significant difference between the mean value of bleeding time of experimental groups ۱, ۳ and ۴ in comparison to the control group (P≤۰.۰۵). Based on the findings, it is concluded that an aqueous extract of ۴۰۰ mg/kg. BW C. capsicum can be used to enhance the speed of coagulation. Since different doses of aqueous extract of T. capsicum show different results on the bleeding time, this extract can be used at low doses to enhance platelet activation and for people who are prone to blood clotting and thus prone to different strokes; the high doses of this extract prevent the formation of unwanted blood clots.

Keywords:

extract of T. capsicum , prothrombin time , thromboplastin time , bleeding time , عصاره زنیان , زمان پروترومبین , زمان ترومبوپلاستین , زمان سیلان