Systematic Review of The Molecular Diagnosis of The Endometrial Carcinoma

Background: Today, the diagnosis and staging of endometrial cancer are surgical and pathological procedures, but other non-invasive diagnostic methods, such as molecular diagnostic methods are being used with caution. So, this study aimed at reviewing current molecular diagnostic methods to clarify available methods for further accuracy analyses.  Methods: This was a systematic review. PubMed and Scopus databases were queried with relevant.  All articles related to the topic were selected. Then, the search results were reviewed based on the relationship between the title of the article and then the abstract and text of the article with the aim of research. The articles found were published in the period ۲۰۰۸ to ۲۰۲۲. Only qualitative analysis was performed.  Results:  Finally, ۱۱ retrospective studies were found along with a meta-analysis study.  CA-۱۲۵, HE۴, Serum-Amyloid-A, Sperm-associated antigen ۹, YKL-۴۰, and Visfatin were individual factors assessed as diagnostic or prognostic factor along with some studies evaluating panel of proteins for prediction of the endometrial cancer. Most studies showed valuable diagnostic features of the evaluated proteins and panels versus being prognostic.  Conclusion: Advances in molecular biology in recent decades have helped enhance researchers' to predict endometrial cancer that available choices should be more evaluated for preparation for clinical use.   

Keywords:

Endometrial cancer , Endometrial carcinoma , Molecular biomarker , Visfatin , CA-۱۲۵ , HE۴