Hearing Threshold of Auditory Brainstem Response in Term Neonates with Hyperbilirubinemia

Background:Neonatal jaundice is a common cause of premature neonatal hearing loss and is a major cause of childhood deafness, especially in developing countries. The aim of this study was evaluating Hearing threshold of Auditory Brainstem Response (ABR) in term neonates admitted with hyperbilirubinemia at a range of exchange transfusion and near exchange transfusion. Methods: This cross-sectional study was performed on ۱۳۴ healthy term infants admitted due to hyperbilirubinemia in the neonatal care unit of Besat Hospital in Hamadan from March ۲۰۱۷ to September ۲۰۱۷. All neonates were evaluated by Otoacoustic Emission (OAE) and ABR after admission in neonatal ward and after treatment by intensive phototherapy or blood              exchange. Data were collected and analyzed through SPSS software and using Chi-square and Mann-Whitney tests. The significance level was considered at ۰.۰۵ for all statistical tests. Results: The mean weight of newborns was ۳۰۰۰ ±۳۵۰ gr and the mean of gestational age was ۳۹± ۲ weeks. Bilirubin concentration of the infants was ۳۶.۹±۹.۲ mg/dL. There was a significant difference between hearing loss on auditory brainstem response in term neonates according to hyperbilirubinemia in blood exchange range (P = ۰.۰۰۱). However, there was no significant difference between hearing loss on auditory brainstem response in term neonates according to the gestational age, sex and phototherapy (P > ۰.۰۵). Conclusion: Our findings indicated that high bilirubin levels in the range of exchange transfusion can be an important risk to the auditory system, which without creating kernicterus, can interfere with auditory tests.

Keywords:

Hyperbilirubinemia , Auditory Brainstem Response , term Neonate exchange transfusion