A comparative study of chemical compounds and antibacterial activity of medicinal plants of Dracocephalum Lindbergii Rech.f and Dracocephalum subcapitatum (kuntze) Lipsky growing in North Khorasan province, Iran
Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JKMU-26-2_004
تاریخ نمایه سازی: 19 دی 1401
Abstract:
Background: A number of aromatic medicinal plants used for treating infection disease have been mentioned in different phytotherapy manuals due to their availability, fewer side effects, and reduced toxicity.Dracocephalum L is one of the most important genuses of Lamiaceae.The aim of our study was to evaluate the chemical compositions of Dracocephalum Lindbergii Rech.fand Dracocephalum subcapitatum (O.kuntze) Lipskyand there is antimicrobial activites. Methods: Two species of Dracocephalum (Dracocephalum Lindbergii Rech.fand Dracocephalum subcapitatum (O.kuntze) Lipsky ) were collected at North Khorasan province.Extracting the essential oil of the aerial parts of the plant was done through the method of hydrodistillation using Clevenger, and the identification of the essential oils components were carried out through GC-MS. The antibacterial activity was performed against three human pathogenic bacteria including:Escherichia Coli,Staphylococcus aureus, Bacillus atrophaeuse, using disk diffusion method. Results: Forty-two components were identified in the essential oil of the species Deracocephalum Lindbergii Rech.f., representing ۹۰.۶۹% of the total oil. The highest percentage of the components belongs to β-ocimene with ۱۷.۵۸%. Thirty components were identified in the plant Deracocephalum subcapitatum (O.kuntze) Lipsky, representing ۸۷.۲۴% of the total oil, in which the highest percentage belongs to β-ocimene with ۲۴.۴۵%. The antibacterial effects showed that the bacteria of Bacillus atrophaeus and Staphylococcus aureus with the diameter inhibition zones of ۲۹ and ۳۳ mm were the most sensitive. In addition, the essential oil of D.subcapitatum (O.kuntze) with a diameter of ۳۳ mm inhibition zone had the highest antibacterial activity against Staphylococcus aureus bacteria. Conclusion: Based on the results of this study,the chemical variations of the volatile oils of two Dracocephalum species might be correlated with geographical regions and enviromental conditions play a significant role in biosynthesis of the components of the oil. Also,The results of the antibacterial examination of the essential oil s of the studied species can lead to the discovery of new antibacterial agents.
Keywords:
Essential oil , Antibacterial Activity , Dracocephalum Lindbergii Rech.f , Dracocephalum subcapitatum (O.kuntze) lipsky , GC-MS
Authors
Reza Rezazadeh
M.Sc Student, Department of Chemistry , Slamic Azad University, Bojnourd, Iran
Ali Firoznia
Assistance Professor, Department of Chemistry , Slamic Azad University, Bojnourd, Iran
majid halimi
Assistance Professor, Department of Chemistry, Payame Noor University, Tehran, Iran
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