Background: Lead poisoning is an issue of concern in developing countries and high levels of lead in blood could be resulted following occupational and environmental exposures. Several reports have raised concerns on the increasing prevalence of lead intoxication among opioid addicts. This study investigated the clinical manifestations and demographic data of subjects who were diagnosed with lead poisoning and also possible correlations of job type and opium abuse with lead poisoning. Methods: This cross-sectional study was carried out on ۸۲ patients admitted to Imam Reza Hospital, Mashhad, from ۲۰۰۴ to ۲۰۱۶ with the diagnosis of lead poisoning. Demographic information, clinical signs and symptoms, as well as, hematological and biochemical profiles and their possible correlations were investigated. Opium-addiction status was judged based on patient self-report. Results: In this study, ۸۲ patients were admitted to Toxicology Department. Patients’ age ranged between ۱۹ and ۸۱ years old (mean ±SD: ۴۲.۲±۱۴.۹۰) and ۷۸ patients were male (۹۵.۱%). With regard to the occupational exposure, ۲۹ individuals (۳۵.۴%) had occupational risk factors for lead poisoning; however, no significant relation was found between the type of occupation and blood lead level (p=۰.۹۵). Moreover, ۴۳ individuals (۵۲.۴%) were opioid-addicted but opioid addiction was not significantly correlated with blood lead level (p=۰.۹۱). Among all, ۷۰ individuals (۸۵.۴%) were anemic and with increasing blood lead level, the levels of Hb (p= ۰.۰۱۱, r= -۰.۲۷۹) and Hct (p=۰.۰۰۳, r= -۰.۳۳۲) showed significant decrease. Conclusion: Though blood lead level was not significantly correlated with opioid addiction, but most of patients were opioid addicts. Apparently, public awareness and health-care-providers’ knowledge should be improved about the potential hazardous effects of using adulterated opium.