Specific and Non-Specific Thalamocortical Afferents to the Whisker–Related Sensory Cortical Region in Rats with Congenital Hypothyroidism
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JKMU-22-4_003
تاریخ نمایه سازی: 19 دی 1401
Abstract:
Background & Aims: Thyroid hormones are of great importance in the development of the central nervous system. Congenital hypothyroidism may affect the reorganization of specific and non-specific thalamocortical afferents to whisker–related sensory (wS۱) corticol region in rats. Methods: Congenital hypothyroidism was induced by adding propylthiouracil (PTU) (۲۵ ppm) to the rats’ drinking water from embryonic day ۱۶ to postnatal day ۶۰. Pregnant rats were divided into normal and congenital hypothyroidism groups. Wheat germ agglutinin-horseradish peroxidase (WGA-HRP) was injected into wS۱ cortical area as tracer. Results: Following tracer injection, retrogradely labeled neurons were observed in the thalamic specific relay nuclus including ventral posterior medial (VPM), and in the nonspecific thalamic nuclei including centrolatral (CL), centromedial (CM), ventromedial (VM), posteromedial (PO), and reunion (Re). The number of VPM and PO labeled neurons significantly reduced in the congenital hypothyroidim group compared to the normal group (P < ۰.۰۱ and P < ۰.۰۵, recpectively). No significant difference was observed between the hypothyroidism group and control group in terms of the number of labeled projection neurons in CL, CM, VM, and Re nuclei. Conclusion: The present study showed that congenital hypothyroidism alters the thalamocortical projection pattern from VPM and PO thalamic nuclei to barrel cortex
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Authors
Mohammad-Reza Afarinesh
Ph.D. of Physiology, Neuroscience Research Center, Institute of Pharmachology, Kerman University of Medical Sciences, Kerman, Iran & School of Medicine, Shahid Beheshti University of Medical Sciences,Tehran, Iran
Gila Behzadi
Professor of Physiology, School of Medicine & Functional Neuroanatomy Laboratory, Neurophysiology Research Center, Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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