Evaluation of the FAS and FASL Gene changes in women with premature ovarian failure: A case-control study

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJRM-20-12_002

تاریخ نمایه سازی: 20 دی 1401

Abstract:

Abstract Background: Premature ovarian failure (POF), is menopause occurring before the age of ۴۰, affecting ۱-۳% of women worldwide. The risk of POF increases with altered immunological parameters such as FAS and FASL genes, which play a fundamental role in embryogenesis and cellular homeostasis. Objective: The study aimed to investigate the potential role of FAS and FASL genes in POF pathogenesis. Materials and Methods: In this case-control study, the polymorphisms of FAS-۶۷۰A/G and FASLIVS۲nt_۱۲۴A/G apoptotic genes were analyzed in ۵۱ Iranian women suffering from POF, and ۶۱ healthy controls. Isolation of DNA was done using the salting-out method, and genotypic analysis was performed for all the subjects using the polymerase chain reaction-restriction fragment length polymorphism method. Results: Our results revealed that homozygous FAS-۶۷۰A/A and G/G, and heterozygous FAS-۶۷۰A/G are not significantly different between cases and controls (p = ۰.۹۹). Also, in different genotyping models of FASIVS۲nt_۱۲۴, polymorphisms were not related to POF risk (p = ۰.۲۳). Conclusion: There is no statistical association between these polymorphisms and POF risk in women referred to genetic counseling clinics.

Authors

Zhima Akhavansales

Department of Immunology, Faculty of Medicine, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Alimohammad Mosadegh Mehrjardi

Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Hamid reza Ashrafzadeh

Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Shadnaz fakhteh Yavari

Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.

Mohammad Taher Tahoori

Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Morteza Bitaraf Sani

Animal Science Research Department, Yazd Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education & Extension Organization (AREEO), Yazd, Iran.

Mahnaz Mohammadi

Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Fateme Montazeri

Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Nasrin Ghasemi

Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

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