Reverse Phase HPLC Method for the Simultaneous Determination of Cetirizine, Verapamil/Diltiazem and Amlodipine
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ANALCH-8-2_003
تاریخ نمایه سازی: 16 بهمن 1401
Abstract:
Determination of cetirizine, diltiazem, or verapamil and amlodipine in an active and in dosage formulations has been performed using a simple RP-HPLC method. Rosuvastatin is used in this novel RP-HPLC method as an internal standard to improve the selectivity of the method. At ۲۳۰ nm, the separation was performed using a mobile phase consisting of methanol, acetonitrile, and water mixture in a ratio of ۶۵:۵:۳۰, and pH at ۲.۸ allowed improved separation and faster times of analysis. ICH guidelines have pursued the validation of the method by assessing accuracy, precision (%RSD>۲), and linearity (>۰.۹۹۹). The retention times of diltiazem, verapamil, amlodipine, cetirizine, and rosuvastatin was found to be ۲.۵, ۳.۲, ۴.۱, and ۶ minutes, respectively. Method specificity was good as no interference of excipients of the tablets were observed in the analysis. The developed method could be used for routine quality control and in biological samples for the analysis of these drugs.
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Authors
Hina Shamshad
Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi, ۷۵۲۷۰, Pakistan
Asia Naz
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi
Agha Zeeshan Mirza
Chemistry Department, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia
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