The Effect of Vitamin E and Selenium on Sperm Chromatin Quality in Couples with Recurrent Miscarriage
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
View: 118
This Paper With 10 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_JIML-5-1_001
تاریخ نمایه سازی: 7 اسفند 1401
Abstract:
Background and Aims: Due to the paucity of studies, association between the morphology and function of sperm and recurrent miscarriage (RM) is not yet completely known. Increased reactive oxygen species and decreased antioxidant levels in men have been shown to be associated with RM. Recently it has been accepted that antioxidant therapy can approve sperm parameters. The goal of this study was to evaluate the effect of paternal factor and antioxidant therapy on sperm parameters in the couples with RM.
Materials and Methods: Sixty ejaculate samples with RM patients were analyzed before and after ۳ months of vitamin E and selenium therapy. Sperm chromatin assay was assessed by cytochemical tests including aniline blue, chromomycin A۳, and toluidine blue. To measure DNA fragmentation index, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) test was used. Data were analyzed by SPSS software.
Results: Patients had significantly higher percentage of sperm parameters (p<۰.۰۰۱) compared to the time before treatment. TUNEL positive spermatozoa were decreased in post treatment compared to pre-treatment phase (p<۰.۰۰۰۱).
Conclusions: Our study demonstrates that antioxidants can improve sperm parameters and chromatin condensation in recurrent miscarriage male partner.
Keywords:
Authors
Soheila Pourmasumi
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Nasrin Ghasemi
Recurrent Abortion Research Center, Research and Clinical Center for Infertility, Shahid Sadughi University of Medical Sciences, Yazd, Iran.
Ali Reza Talebi
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mehrnaz Mehrabani
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Parvin Sabeti
Department of Anatomical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran.
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :