Determining the Change of Hormonal and Biochemical Parameters in the Thalassemia Major Patients Over ۳ Years

Background: Endocrinopathies are common complications in Thalassemia Major (TM) patients. They are important as secular trends of complications in childhood as a critical period for growth and development. The present study, then, aimed to investigate these complications in children and young adults.Methods: ۳۴ TM patients, with the mean age of ۱۹ ± ۶ y/o, entered this study. Female to male ratio was ۲۱/۱۳. Their medical history was obtained by review of medical records. Data about FBS, AST, ALT, TG, cholesterol, and ferritin, TSH, LH and FSH was collected. Due to the lack of normality of some continuous variables, an appropriate transformation method was implemented to convert them to normal distribution. Repeated measure ANOVA was used to assess change of outcomes across time. Correlations between different parameters were also calculated.Results: After ۳ years, only FBS changed significantly in comparison to phase ۱ and ۲ results (P-value=۰.۰۲۸).  Ferritin in the first phase significantly correlated with ALT (P-value = ۰.۰۲۱), in the second phase with AST (P-value=۰.۰۲۹) and ALT (P-value=۰.۰۰۲) and in the third phase with FSH, LH and TG (P-value=۰.۰۴۷, ۰.۰۲۰, ۰,۰۲۷, respectively). In the first phase AST correlated with TG and cholesterol (P-value=۰.۰۱۵, ۰.۰۰۱, respectively) and ALT with cholesterol (P-value <۰.۰۰۱). ALT correlated with TG in the second phase (P-value=۰.۰۴۰). ALT and AST correlated with cholesterol in the third phase (P-value=۰.۰۰۲, ۰.۰۰۷, respectively).Conclusion: Hormonal parameters do not show significant change during a ۳ years period in TM patients.

Keywords:

Thalasemia , , , , , Bichemistry , , , , , Hormone , , , , , cohort