One-pot four-component synthesis of pyrimido[۲,۱-a]isoquinoline-۳,۴- dicarboxylate derivatives via the reaction of phthalaldehyde, ammonium acetate and dialkyl acetylenedicarboxylates in the presence of phenyl isocyanate derivatives
Publish Year: 1401
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
CCES18_001
تاریخ نمایه سازی: 10 اسفند 1401
Abstract:
The reaction of phthalaldehyde, ammonium acetate and dialkyl acetylenedicarboxylates in the presence of phenyl isocyanate derivatives to proceeded at room temperature and under mild conditions to afford synthesis of dialkyl-۱-(۴-(alkyl)phenyl)-۲-oxo- ۱,۱۱b-dihydro-۲H-pyrimido[۲,۱-a]isoquinoline-۳,۴-dicarboxylate derivatives in excellent yields. All products were established by IR, ۱H, ۱۳CNMR, Mass spectroscopy and elemental analysis.
Authors
Milad Bazaz Rastkar
Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran