Chromoblastomycosis successfully treated with the combination of itraconazole and ۵-flucytosine

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
View: 126

This Paper With 7 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_CMBR-3-3_004

تاریخ نمایه سازی: 12 فروردین 1402

Abstract:

Chromoblastomycosis (CBM) is a fungal disease, distributed in tropical and subtropical regions, affecting mainly rural workers. It is characterized by chronic skin lesions that may vary from nodular, tumorous, verrucous or plaque type. Associated constitutional symptoms are rarely found. The histological presentation may yield a pathognomonic feature, the Medlar (sclerotic) bodies, in which a typical brown to black pigment is depicted, explaining “copper pennies” as its alias. In this article, the case of a ۵۶-year-old woman in the countryside of Brazil is reported; whose main complaint was a chronic leg ulcer for the past ۸ years. On the left leg, a large, partially ulcerated plaque lesion was found. Microbiological cultures were positive for the pathogen. Histological analysis demonstrated pseudoepitheliomatous hyperplasia, lymphohistiocytic infiltrate and sclerotic bodies (“copper pennies”). CBM’s epidemiological panorama, once established uniquely by geographical distribution, is transitioning to a global health issue, influenced by immunosuppressive conditions, global warming and migration. This scenario demands CBM to be widely considered as a differential diagnosis and may represent a clinical challenge in regions whose professionals have little expertise in infectious tropical diseases.

Authors

Reginaldo Gon De Lima-Neto

Center of Medical Sciences, Department of Tropical Medicine, Federal University of Pernambuco (UFPE), Recife-PE ۵۰۷۴۰-۶۰۰, Brazil

Mohammad Reza Mohammadi

Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :