Application of Multivoxel ۱H-Magnetic Resonance Spectroscopy in the Grading of Cerebral Glioma

Introduction: Gliomas represent a considerable percentage of all diagnosed primary central nervous system tumors. A non-invasive access method, like magnetic resonance spectroscopy (MRS), is required for preoperative evaluation. So, the present study aimed to evaluate the application of Multivoxel ۱H-MR Spectroscopy in the differentiation of high-grade from low-grade gliomas.Material and Methods: ۱۳ patients suspected of Cerebral Glioma, which already had been selected for brain surgery or biopsy, underwent a Multivoxel ۱H-MR Spectroscopy. After the MRS exam, the pathology tests on specimens confirmed the grade of tumors. Then results were compared and represented as receiver operating characteristic (ROC) curves to show their sensitivity and specificity as well.Results: Choline to creatine (Cho/Cr) and choline to N-acetyl-aspartate (Cho/NAA) were statistically lower in the low-grade group than in high-grade (p=۰.۰۰۷ and p=۰.۰۲۷, respectively) and N-acetyl-aspartate to creatine (NAA/Cr) was statistically higher in the high-grade group (p=۰.۰۳۷). But in border regions, only Cho/Cr and Cho/NAA were significant (P values= ۰.۱۹ and ۰.۲۲, respectively). With receiver operating characteristic (ROC) curves analysis, Cho/Cr had the best sensitivity and specificity in the differentiation of high-grade from low-grade gliomas in tumor area (۹۲.۸۶% sensitivity and ۸۵.۷۱% specificity) and this ratio had the best sensitivity and specificity in border regions of tumor (۹۲.۸۶% sensitivity and ۷۸.۴۳% specificity).Conclusion: Metabolite ratios of low and high-grade gliomas (HGG) were significantly different from each other. Cho/Cr and Cho/NAA ratios can use as an internal reference for grading the glioma non-invasively in the tumor area and the border area of the tumor.

Keywords:

Magnetic Resonance Spectroscopy , Neoplasms , Neoplasm Grading