Intensity Modulated Radiation and Volumetric Modulated Arc Therapies in Breast Cancer

Background: Breast cancer is the most common malignant neoplasm in women, accounting for ۲۵% of all cancers. Radiotherapy is one of the safest methods compared with other treatments.Methods: In this study, ۸ patients with left breast cancer underwent the radiation therapy. After simulating the tomographic data of breast cancer patients, treatment planning was performed in the treatment planning system, and then the clinical target volume and the planned target volume were determined.Results: The mean CI (۱.۱۶۲ ± ۰.۰۱۱) in Intensity Modulated Radiation Therapy (IMRT) was significantly lower than CI (۱.۱۷۳ ± ۰.۲۸) in Volumetric Arc Radiation Therapy (VMAT) (P ≤ ۰.۰۲), indicates that IMRT technique had lower CI which means better dose conformity within the PTV. Also, the mean HI (۰.۶۹۶ ± ۰.۳۳۳) in VMAT was significant compared to IMRT, the mean HI (۰.۵۵۸ ± ۰.۲۸۸) (P ≤ ۰.۰۴), the results on better PTV dose distribution by using VMAT technique. Planning target volume (PTV) was consistent with indicators and PTV coverage value (۹۷.۵۶۳ ± ۱.۴۷۱) in IMRT and (۹۶.۶۷۷ ± ۱.۰۱۸) in VMAT, means that the PTV coverage was better by using IMRT technique rather than VMAT. The mean dose to left breast was (۴۲.۱۱۸ ± ۰۴۶۴) prescribed dose. Ref. vol. CC, D۲%, and D۹۸% were received (۷۳۶.۸۹۸ ± ۲۳۵.۱۴۰), (۴۶۱۸.۹۳۱ ± ۱۰۷.۶۵۸), and (۳۷۶۵.۴۷۵ ± ۷۱.۱۹۵), respectively.Conclusion: IMRT method is one of the new cancer treatment techniques that in comparison with other methods by accurately targeting cancer cells and tumors, it has the least impact on healthy tissues and reduces the side effects as much as possible.

Keywords:

breast cancer , dosimetric , Intensity modulated radiation therapy , volumetric modulated arc therapy